Synthesis and Biological Evaluation of N1-[(3z)-5-Substituted-2-Oxo-1, 2-Dihydro-3H-Indol-3-Ylidene]-5H-Dibenzo [b,f] Azepine-5-Carbohydrazides
نویسندگان
چکیده
منابع مشابه
5-(Prop-2-ynyl)-5H-dibenzo[b,f]azepine
The asymmetric unit of the title compound, C(17)H(13)N, contains two independent butterfly-shaped mol-ecules. The seven-membered azepine rings both adopt a boat conformation. The dihedral angles between the benzene rings in the two mol-ecules are 46.95 (11) and 52.21 (11)°.
متن کاملMethyl 2-(5-chloro-1-methyl-2-oxo-2,3-dihydro-1H-indol-3-ylidene)acetate
The title compound, C12H10ClNO3, the indoline ring system is essentially planar, with a maximum deviation of 0.009 Å for the N atom. The indoline ring and acetate group are essentially coplanar, with a maximum deviation of 0.086 Å for the O atom. The mean plane through the methoxy-carbonyl-methyl group forms a dihedral angle of 3.68 (5)° with the plane of the indoline ring system. The mol-ecula...
متن کامل5-Methyl-N′-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-1-phenyl-1H-1,2,3-triazole-4-carbohydrazide
In the title compound, C18H14N6O2, the benzene ring is slightly twisted out of the plane of the 1,2,3-triazole ring (r.m.s. deviation = 0.010 Å), forming a dihedral angle of 6.20 (13)°. The nine non-H ring atoms of the fused five- and six-membered ring system are almost coplanar (r.m.s. deviation = 0.032 Å). The near coplanarity in the central residue is consolidated by an intra-molecular bifur...
متن کاملSynthesis and Antibacterial Evaluation of (S,Z)-4-methyl-2-(4-oxo-5- ((5-substituted phenylfuran-2-yl) methylene)-2-thioxothiazolidin-3-yl) Pentanoic Acids
The resistance of antimicrobials has become a global hazard with the irrational use of antibiotics. Infection of drug-resistance bacteria seriously threatens human health. Currently there is an urgent need for the development of novel antimicrobial agents with new mechanisms and lower levels of toxicity. In this paper, a series of (S,Z)-4-methyl-2-(4-oxo-5-((5-substitutedphenylfuran-2-yl) methy...
متن کاملN-{2-Methyl-5-[(5-oxo-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-2-yl)amino]phenyl}benzamide
In the title compound, C(29)H(24)N(2)O(2), the two aromatic rings of the tricyclic unit are oriented at a dihedral angle of 32.27 (8)°. In the crystal N-H⋯O hydrogen bonds link the mol-ecules into chains along the a axis. Further N-H⋯·O inter-actions link the chains.
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ژورنال
عنوان ژورنال: International Journal of Biological Chemistry
سال: 2009
ISSN: 1819-155X
DOI: 10.3923/ijbc.2010.19.26